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What is amoxicillin?

Amoxicillin is a drug derived from penicillin and is therefore an antibiotic, which is used to fight bacteria that attack the body. It is used as a treatment for different types of infections caused by bacteria such as bladder infections, gonorrhea, pneumonia, ear infections and salmonella.

Amoxil (the trade name for amoxicillin) is often used with another antibiotic called clarithomycin to treat gastric ulcers caused by Helicobacter pylori infection. This combined treatment requires the use of stomach acid reducers such as omeprazole or lansoprazole, among others.

Composition

This drug is available in different pharmaceutical forms.

For example, the pediatric suspension contains 125 mg or 250 mg of amoxicillin in each dose.

For pediatric use, it is also available in oral drops.

It is also marketed in capsules of 250 mg and 500 mg; and in chewable tablets of 250 mg.

Pharmacological action

Amoxicillin is a broad-spectrum synthetic penicillin and is also a bactericide used orally in all presentations. It is activated by inhibition of the biosynthesis of mucopeptides found in the bacterial wall at the stage of multiplication in process.

In vitro studies demonstrated that the sensitivity of most strains of the following gram-positive bacteria Diplococcus pneumoniae, Streptococcus alpha and beta hemolytic streptococci, Streptococcus faecalis, non-penicillinase-producing staphylococci.

Likewise, this drug is active in vitro against several strains of Neisseria gonorrhoeae, Haemophilus influenzae, Proteus mirabilis and Escherichia coli. Amoxicillin is not effective against penicillinase-producing bacteria, especially resistant staphylococci. All strains of Pseudomonas and many strains of Klebsiella and Enterobacter are resistant.

Indications

Amoxicillin is indicated for the treatment of dermatological, respiratory, stomatological, otorhinolaryngological, gynecological, urogenital, biliary and digestive infections caused by germs sensitive to this antibiotic.

Dosage

The dosage of amoxicillin depends on the disease to be treated.

Amoxicillin should be taken or administered to children as directed by the physician. Do not take higher or lower doses than those indicated by the health care professional. It can be taken with or without food, but the capsules should not be chewed, crushed or broken. In case of any unusual symptoms, patients should immediately contact their physicians.

In the case of the pediatric oral suspension 125 mg, a dose of 5 ml every 8 hours is recommended. In the case of the 250 ml pediatric suspension, a dose of 2.5 ml every 8 hours is recommended. This dosage will depend on the disease being treated and the physician will determine the adjustment according to the child's age, weight and the condition being treated.

Pediatric dosages (per kilogram of weight) are indicated in patients whose weight does not warrant the use of doses higher than those recommended for adults.

Adults will be treated with capsules or chewable tablets according to medical criteria. The usual dose is one capsule or tablet every 8 hours but the physician will decide the dosage according to the disease to be treated and the patient's condition.

Pediatric drops are primarily indicated in children under 6 months of age. The usual dose is 25-50 mg/kg/day administered in three equal doses, according to medical criteria.

In case of overdosage, amoxicillan can be removed from the circulation by hemodialysis. Overdosage may cause gastrointestinal symptoms such as diarrhea, vomiting and nausea.

In patients with renal insufficiency, dosage adjustment is generally not necessary unless renal impairment is very severe. Patients on hemodialysis should be given 250 or 500 mg every 24 hours, depending on the severity of the infection. They will receive an additional dose during hemodialysis and a further dose at the end of hemodialysis.

Adverse effects

Patients indicated to use amoxicillin as antibiotic treatment should seek emergency medical attention immediately if they experience symptoms of an allergic reaction to the drug (rash, itching, hives, swelling of the mouth, lips, face or tongue), bloody stools, dark urine, confusion, chills, fever, skin blisters, stomach pain and cramps, vaginal irritation or discharge, unusual bleeding or bruising, yellow skin.

On the other hand, hypersensitivity reactions such as maculopapular erythematous rash, Stevens-Johnson syndrome, erythema multiforme and respiratory disorders should be considered. Other very infrequent adverse reactions are epidermal toxic necrolysis and anaphylactic shock. In relation to the digestive system: nausea, diarrhea, vomiting and candidiasis, and very rarely transient and moderate elevation of transaminases.

Likewise, during treatment with amoxicillin, anemia, thrombocytopenic purpura, eosinophilia, agranulocytosis and leukopenia have been reported, which have been reversible.

Contraindications

Amoxicillin is contraindicated in patients who have a history of hypersensitivity to the group of antibiotics called penicillins or to any other component of this medicinal product; herpes virus infections, infectious mononucleosis.

Drug-drug interactions

Patients should tell their physicians about any medications they are taking so that the practitioner can safely consider drug-drug interactions.

It is not advisable to administer allopurinol together with amoxicillin because this increases the risk of skin reactions. Likewise, sulfonamides, chloramphenicol and erythromycin can decrease the effectiveness of amoxicillin. On the other hand, amoxicillin can decrease the effectiveness of oral contraceptives, so the use of an additional contraceptive method during treatment with this drug is recommended.

Regarding the interaction of amoxicillin in laboratory tests, when the treatment with this antibiotic involves very high doses, it may decrease the results of blood glucose levels.

Presentation

Pediatric oral suspension (also in sachet), capsules, chewable tablets and pediatric drops.

Keep this and all medications out of the reach of children. Store in a cool place.

After preparing the suspension, it can be stored for 7 days at room temperature or 14 days in the refrigerator.

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