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What is Nolvadex?

The active substance of the drug is an antiestrogen tamoxifen, which blocks female sex hormones estrogens. Thus, the generic prozac moderates the undesirable growth-promoting effect of estrogen hormones on cells and is therefore used for palliative or supportive treatment of breast cancer.

The active substance is used for further curative treatment after initial therapy of breast cancer. It is also used for the treatment of breast cancer tumor metastases.

Dosage and use

The dosage of the drug is between 20 and 40 mg of Tamoxifen, that is from one to two pills per day. Usually a dosage of 20 mg of the drug is enough.

It is necessary to take the pills unchewed with water while eating.

name="Bookmark"> The treatment is usually a long-term therapy and should be carried out only under the supervision of doctors who have experience with cancer diseases. In the post-treatment of breast cancer detected and removed at an early stage, the recommended duration of treatment is at least five years. Only the doctor has to decide about the duration of the therapy. 

It is necessary to take Tamoxifen according to the prescription of your doctor.

Use in children and adolescents

The use of the drug in children and adolescents is not provided because safety and effectiveness of this age group are not proved.


In case of overdose (it means when you have taken a lot of tablets) it is necessary to contact your doctor.

If the patient missed the dose of the medication he/she should not take the doubled dose. You should take the next dose according to the doctor's prescription, as usual.

You do not have to stop therapy without consulting your doctor. The therapy effect may be jeopardized.

If you have any questions about how to use the medication consult your doctor.

Side effects

Every person reacts differently to medications. Both this drug and other drugs may cause side effects. Among very common side effects are headache, flushing, changes in menstrual cycle, menstrual suppression, discharge, drowsiness, anemia, vision problems, retinal damage, nausea, skin rashes, hair loss, fluid retention in the body, cramps in the legs, bone pain, , vaginal bleeding, fibroid enlargement, vaginal bleeding, pain at the tumor site, tissue growths on the lining of the uterus e. For example, such as endometriosis and endometrial polyps, itching in the genital area, vomiting, blood count disorders, leukopenia, thrombocytopenia, sensitivity disorders , strokes, liver cirrhosis, pancreatitis, endometrial cancer, jaundice, diarrhea and constipation, and others.

If you experience side effects talk about it with your doctor.

Drug interactions

Hormonal drugs, especially estrogens, cause decrease in effect of this drug.

In simultaneous use of tamoxifen and letrozole, which prevents estrogen formation, blood level of letrozole was decreased by 37%.

Taking the remedy with antiplatelet agents increases the risk of bleeding. The same interaction has the use of the drug with warfarin. Tamoxifen increases the risk of blood vessel blockages. Simultaneous therapy with chemotherapeutic agents such as antibiotics and other cytostatics increases this incidence.

Such active substances, which inhibit the enzyme CYP2D6, also inhibit the effect of the active substance generic accutane pills. Simultaneous intake of antidepressants of the group of selective serotonin reuptake inhibitors (such as paroxetine) or other antidepressants such as fluoxetine or bupropion, the antiarrhythmic quinidine, cinacalcet should possibly be avoided. As antidepressants the doctor should prescribe such preparation as venlafaxine because it does not inhibit this enzyme.

Tamoxifen should not be taken in case of allergy to the active substance.

Pregnancy information

The drug should not be used during pregnancy. Malformations have been shown in animals. Pregnancy should be ruled out before starting treatment with Tamoxifen, and safe contraception must be ensured during curative treatment as well.

During treatment with Tamoxifen or 3 months after the patient has stopped taking the drug, she must not become pregnant. Pregnancy prevention is absolutely necessary. Before starting the treatment, the woman must be examined by a gynecologist. It is necessary to exclude pregnancy.

This medicine reduces lactation in women. Lactation does not resume after the end of the treatment. Therefore, breastfeeding is not possible during treatment with this drug. Thus, either breastfeeding must be stopped or the drug cannot be used for the breastfeeding period.

The remedy cannot be used by the children.

Taking the drug while operating machinery

Some side effects of the remedy, such as dizziness or clouding of consciousness and impairment, fatigue, drowsiness may damage your ability to concentrate and judgment. For example, visual disturbances may develop during therapy.

If the speech is about you, do not drive a vehicle, operate machinery under any circumstances.

Storage instructions

Keep the medicine in a cool, dry place and out of the reach of children.

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